Function of Rho GTPase Activating Protein 11A in Tumors

ARHGAP20 (Rho GTPase activating protein 20)

Characterization of the Rho GTPase-Activating Protein RhoGAP68F

Rho small GTPases control multiple aspects of neuronal morphogenesis by regulating the assembly and organization of the actin cytoskeleton. Although they are negatively regulated by GTPase activating proteins (GAPs), the roles of RhoGAPs in the nervous system have not been fully investigated. Here we describe a characterization of Drosophila RhoGAP68F that is mainly expressed in the embryonic c...

Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein.

Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization. Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis.

DLC-1:a Rho GTPase-activating protein and tumour suppressor

The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrat...

In-silico designing of novel inhibitors of rho-GTPase activating protein for treatment of glaucoma

Increased intraocular pressure resulting in the optical neuropathy characterised by permanent blindness is called glaucoma. The aqueous humor accumulates in the posterior chamber because of the slower release rate of aqueous humour as compared to the rate of its formation results in increased intraocular pressure, which creates pressure against the optic nerve causing the death of nerve cells. ...